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No file available [This article belongs to Volume - 55, Issue - 2]
Gongcheng Kexue Yu Jishu/Advanced Engineering Science
Journal ID : AES-03-02-2023-516
Title : Synthesis, molecular modeling and anticancer activity of new pyrazole containing compounds
Mariam H. Adel, , Hiba A.Ibraheem,

Abstract : A series of new pyrazole-containing compounds 3a-c were synthesized from chalcone derivatives 2a-c with an excess of hydrazine hydrate under reflux in acetic acid. The structure of the produced compounds was established by Melting point, TLC, FT-IR spectroscopy, and 1H-NMR. The target compounds (3-acetylcoumarin, 2a, 2b, 2c, 3a, 3b, 3c & Pivaloylampicillin) underwent a docking procedure Ampicillin-CTX-M-15. The orthosteric target was shown to bind to every hit. (Active) location of the enzyme, w

Keywords : synthesis, molecular, modeling